Thomas Schindler, M.D.
Background
Thomas Hellmut Schindler, M.D., is Director of Cardiovascular Nuclear Medicine and Associate Professor PER at Johns Hopkins Universiy, Medical School, Baltimore, MD, USA. Dr. Schindler has an international reputation in the field of Cardiovascular Imaging with focus on Nuclear Cardiology and cardiac PET/CT imaging. He received his medical degree (1995) and dissertation (doctor medecinae, 1996) from the University of Leipzig, Germany ("magna cum laude"). He is board certified for Internal Medicine, Cardiology and Nuclear Cardiology. From 2002 to 2006, Thomas Schindler completed a postdoctoral fellowship in cardiac PET imaging at the David Geffen School of Medicine at UCLA (University of California, Los Angeles, Mentor Dr. Heinrich R. Schelbert, MD, PhD). Subsequently, from 2006-2013, Thomas Schindler had joined the faculty of the University of Geneva (Switzerland), initially as assistant professor and clinical attending primarily in charge for Cardiovascular Imaging but also for General Clinical Cardiology, while being promoted academically to "Privat-Docent" in 2009 and clinically to Deputy Head Physician in Cardiology 2010 in view of his clinical services and training of residents and fellows. He has authored over 71 peer review publications with an impact factor exceeding 287 mainly as first and senior author, and numerous book chapters. He has been member of the board of directors (BOD) of the cardiovascular committees (CVC) of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), Cardiovascular Section (CC) of the European Society of Nuclear Medicine (EANM), and the European Society of Cardiology (ESC) for several years and he is involved in numerous conferences as organizer and invited speaker. Thomas Schindler established Nuclear Cardiology and cardiac PET centers at the Universities of Freiburg (Germany), Basel and Geneva (Switzerland). while performing major contributions in the identification and characterization of coronary circulatory dysfunction, as functional precursor of CAD, by means of PET flow studies during his postdoctoral fellowship at UCLA and subsequently in Geneva (Switzerland). This research provides a frame work for designing treatments strategies for modifying and/or reducing coronary risk. His overall vision is to develop cardiac SPECT- and PET-CT and other cardiac imaging modalities in the clinical routine for the assessment of early and late stages of CAD with its diagnostic and prognostic implications, while pursuing the advancement of molecular imaging in cardiac disease.
Contact
Address Details
601 N. Caroline Street Baltimore, MD 21287
Phone: 410-955-8994 Fax: 443-287-2933
Research & Publications
Research & Publications
Selected Publications
- Schindler TH, Lima JAC. Assessment of myocardial matrix expansion with cardiac magnetic resonance: entering a new area of cardiac risk stratification in type 2 diabetes mellitus? Eur Heart J 2014; 36(10):608-11.
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Quercioli A, Montecucco F, Pataky Z, Harsch E, Thomas A, Ambrosio G, Staub C, Di Marzo V, Ratib O, Mach F, Golay A, Schindler, TH. Improvement of Coronary Circulatory Function in Morbidly Obese Individuals after Gastric Bypass induced Weight Loss – Relation to Alterations in Endocannabinoids and Adipocytokines – Eur Heart J 2013; 34(27):2063-73.
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Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, Camici PG, Cerqueira MD, Chow JW,Di Carli MF, Dorbala S, Gewirtz H, Gropler RJ, Kaufmann PA, Knuuti J, Merhige ME,Rentrop KP, Ruddy TD, Schelbert HR, Schindler TH, Schwaiger M, Sdringola S, Vitarello J, Williams KA, Dilsizian V, Narula J. Anatomic versus physiologic assessment of coronary artery disease: role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making.J Am Coll Cardiol 2013;62(18):1639-53. (Review)
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Schindler TH, Dilsizian V. Cardiac PET-CT Imaging of the Renin-Angiotensin System in Humans Holds Promise for Image-Guided Approach to Heart Failure Therapy. J Am Coll Cardiol 2012; 18;60(24):2535-8 (editorial comment)
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Quercioli A., Pataky Z, Montecucco F., Carballo S, Thomas A, Staub C, Di Marzo V, Vincenti G, Ambrosio G, Ratib O, Golay A, Mach F, Harsch E, Schindler TH. Coronary Vasomotor Control in Obesity and Morbid Obesity: Contrasting Flow Responses with Endocannabinoids, Leptin, and Inflammation. J Am Coll Cardiol Img 2012;5:805-815.
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Quercioli A, Pataky Z, Vincenti G, Makoundou V, Di Marzo V, Montecucco F, Carballo S, Thomas A, Staub C, Steffens S, Seimbille Y, Golay A, Ratib O, Harsch E, Mach, F, Schindler TH. Elevated Endocannabinoid Plasma Levels are Associated with Coronary Circulatory Dysfunction in Obesity. Eur Heart J 2011; Jun;32(11):1369-78.
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Schindler TH, Schelbert HR, Quercioli A, Dilsizian V. Emerging Role of PET Imaging for the Identification and Monitoring of Coronary Artery Disease and Microvascular Health. J Am Coll Cardiol Img 2010; 3:623– 40.
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Schindler TH, Cadenas J, Facta AD, Li Y, Olschewski M, Sayre J, Goldin J, Schelbert HR. Improvement in Coronary Endothelial Function is Independently Associated with a Slowed Progression of Coronary Artery Calcification in Type 2 Diabetes Mellitus. Eur Heart J 2009 Dec;30(24):3064-73.
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Schindler TH, Campisi R, Dorsey D, Prior JO, Facta AD, Zhang XL, Sayre J, Schelbert HR. Beneficial Long-Term Effect of Hormone Replacement Therapy on Coronary Vasomotor Function in Postmenopausal Women with Medically-Treated Coronary Risk Factors. Eur Heart J 2009; 30(8):978-86.
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Schindler TH,Cadenas J, Facta AD, Prior JO, Kreissl M, Zhang XL, Sayre J, Dahlbom M, Julio Licinio, Schelbert HR.Relationship between Increasing Body Weight, Insulin Resistance, Inflammation, Adipocytokine Leptin, and Coronary Circulatory Function. J Am Coll Cardiol 2006;47:1188-1195.
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Schindler TH, Nitzsche EU, Schelbert HR, Olschewski M, Sayre, Mix M, BrinkI, Zhang X-L, Kreissl M, Magosaki M, Just H, Solzbach U. PET-Measured Abnormal Responses of Myocardial Blood Flow to Sympathetic Stimulation are Associated with the Risk of Developing Cardiovascular Events. J Am Coll Cardiol 2005; 45 (9): 1505-1512.
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Schindler TH , Nitzsche EU, Olschewski M, Magosaki N, Mix M, Prior JO,Facta AD, Solzbach U, Just H, Schelbert HR. Chronic Inflammation and Abnormal Coronary Vasomotion. Circulation 2004; 110:1069-1075.
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Schindler TH, Nitzsche EU, Muenzel T, Brink I, Jeserich M, Olschewski M, Buser PT, Matthias Pfisterer M, Solzbach U, Just H. Coronary Vasoregulation in Patients with Various Risk Factors in Response to Cold Pressor Testing: – Contrasting Myocardial Blood Flow Responses to Short- and Long-Term Vitamin C Administration – J Am Coll Cardiol 2003;42(5):814-822
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Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Nitzsche E, Pfisterer M, Solzbach U, Just H. Prognostic Value of Abnormal Vasoreactivity of Epicardial Coronary Arteries to Sympathetic Stimulation in Patients with Normal Coronary Angiograms. Arterioscler Thromb Vasc Biol 2003; 23:495-501.
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Schindler TH, Nitzsche EU, M Olschewski, I Brink, M Mix, JO Prior, A Facta, M Inubushi, H Just, HR Schelbert. PET-measured Responses in Myocardial Blood Flow to Cold Pressor Testing Correlate with Indices of Coronary Vasomotion on Quantitative Angiography. J Nucl Med 2004;45: 419-428.